Portrait of Alejandro Sánchez Alvarado.

Alejandro Sánchez Alvarado receives the Vilcek Prize in Biomedical Science for his contributions to the field of regeneration—from the identification of crucial genes that control regeneration in living organisms, to the potential for regenerative medicine to address how we treat disease in humans.

Born in Caracas, Venezuela, Sánchez Alvarado was fascinated with science from a young age; he was inspired by his high school biology teacher to pursue further studies in molecular biology. Following high school, Sánchez Alvarado was on a track to go to medical school in Venezuela, he convinced his father to let him attend school in the United States for a year, on the condition that if he did well, he could complete his education in molecular biology—the field he was passionate about—in the United States.

While completing his PhD in pharmacology and cell biophysics at the University of Cincinnati School of Medicine, Sánchez Alvarado recalls that while studying embryonic cells, he became—in his own words—“smitten with the plasticity of the genome—how cells channel genetic information to produce specific outcomes.”

Particularly fascinated by the regenerative capabilities of tadpoles under different conditions, Sánchez Alvarado began interrogating what species scientists might study further to better understand the molecular and cellular processes that drive regeneration. He settled on the planarian flatworm, Schmidtea mediterranea, which has become a core subject in his studies.

Alejandro Sanchez Alvarado sitting at his desk.

Sánchez Alvarado is now the executive director and chief scientific officer of the Stowers Institute for Medical Research, and a Howard Hughes Medical Institute investigator. His lab explores the process and genetic control of regeneration and tissue maintenance, and has identified dozens of genes and genetic programs that drive regeneration.

By identifying and characterizing molecular and cellular agents of regeneration, Sánchez Alvarado’s work has the potential to lead to a better understanding of how the adult forms of higher organisms, including humans, carry out their biological functions. His research also has led to insights on the molecular and genetic drivers of both regenerative and degenerative cellular processes that contribute to disease.

Alejandro Sanchez Alvarado looking into a microscope.

Awards and Accomplishments

  • Priscilla Wood Neaves Chair in the Biomedical Sciences (2022)
  • Fellow, American Association for the Advancement of Science (2021)
  • Member, National Academy of Sciences (2018)
  • Member, Latin American Academy of Sciences (2017)
  • Fellow, Marine Biological Laboratory (2016)
  • Member, American Academy of Arts and Sciences (2015)
  • National Institutes of Health, MERIT Award (2009)
  • National Academy of Sciences Kavli Fellow (2008)
  • E.E. Just Award from the American Society for Cell Biology (2007)
Tags
biology biomedical science cell biology cellular regeneration developmental genetics Howard Hughes Medical Institute planaria regeneration stem cells tissue regeneration University of Cincinnati School of Medicine Vanderbilt University venezuela

Jury Members

2023 Vilcek Prize in Biomedical Science

Heran Darwin

Professor, Department of Microbiology, New York University

Titia de Lange

Professor of Physiology and Biochemistry, University of California, San Francisco

Dan R. Littman

Helen L. and Martin S. Kimmel Professor of Molecular Immunology, New York University Langone Health

Joan Massagué

Director, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center

Ruslan Medzhitov

Sterling Professor of Immunobiology, Yale School of Medicine

Xiaowei Zhuang

David B. Arnold Jr. Professor of Science, Professor of Chemistry and Chemical Biology, Professor of Physics, Harvard University

Huda Zoghbi

Professor, Departments of Pediatrics, Molecular and Human Genetics, Neurology and Neuroscience, Baylor College of Medicine

Related Prize Recipients

Angelika Amon

Angelika Amon (1967-2020) receives the Vilcek Prize in Biomedical Science for groundbreaking research on the molecular signals that regulate cell growth and division, and how errors in these processes contribute to birth defects and cancer.
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Xiaowei Zhuang

Xiaowei Zhuang receives the Vilcek Prize in Biomedical Science for developing super-resolution microscopy and genome-scale imaging to directly visualize the structures, activities, and expression profiles of life-sustaining molecules in cells.
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Peter Walter

Peter Walter receives the Vilcek Prize in Biomedical Science for his fundamental insights into the process of protein translocation within cells, and for uncovering signaling mechanisms that cells deploy while facing stress.
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