Xiaowei Zhuang receives the Vilcek Prize in Biomedical Science for developing super-resolution microscopy and genome-scale imaging to directly visualize the structures, activities, and expression profiles of life-sustaining molecules in cells.
Angelika Amon receives the Vilcek Prize in Biomedical Science for groundbreaking research on the molecular signals that regulate cell growth and division, and how errors in these processes contribute to birth defects and cancer.
Richard Flavell receives the Vilcek Prize in Biomedical Science for his paradigm-shifting efforts to use an approach called reverse genetics to probe the molecular basis of immunity, yielding rich insights into innate and adaptive immunity, autoimmunity, and immune system-microbiome interactions.
Ruslan Medzhitov receives the Vilcek Prize in Biomedical Science for pathbreaking work in discovering how immune system proteins called Toll-like receptors shape adaptive immunity, with wide-ranging implications for the fundamental understanding and treatment of inflammation, allergies, and cancer.
Carlos Bustamante receives the Vilcek Prize in Biomedical Science for his pioneering single-molecule studies, which enabled the isolation, visualization, and manipulation of individual molecules within cells and revealed insights into the structure and dynamics of key players in cellular processes such as gene expression.
Harmit Malik receives the Vilcek Prize for Creative Promise in Biomedical Science for uncovering evolutionary insights into the phenomenon of genetic conflict, which arises in a wide range of cellular scenarios and carries implications for proper cell division and immunity against viruses, among others.
Huda Zoghbi receives the Vilcek Prize in Biomedical Science for pioneering work that led to a molecular understanding of Rett syndrome, a rare but devastating inherited neurological condition, and related disorders, revealing insights into brain development and neurodegeneration.
Joan Massagué receives the Vilcek Prize in Biomedical Science for groundbreaking work in identifying and uncovering the mode of action of cellular receptors for the signaling molecule TGF-beta, which is implicated in processes such as embryonic development, tumor onset, and cancer metastasis.