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Home > Prizes > Prize Recipients > Harmit Malik

Harmit Malik

2010 Vilcek Prize for Creative Promise in Biomedical Science

Location

Seattle, WA

Title

Adjunct assistant professor, Department of Genome Sciences, University of Washington, Seattle; Early Career Scientist, Howard Hughes Medical Institute

Area(s) of Research

Biochemistry and genomics; genetic conflicts of centromeres

Education

Fred Hutchinson Research Center (postdoc);
University of Rochester (PhD, Sproull Fellowship);
Indian Institute of Technology, Bombay (BS)

Country of Birth

India

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Links to learn more about Harmit Malik's work
  • fhcrc.org

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biochemistry biology genetics genome Howard Hughes Medical Institute india University of Washington
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A photo of Harmit Malik
Photo courtesy of Fred Hutch

Harmit Singh Malik describes his scientific research as an “evolutionary arms race,” whose combatants are microscopic genes, each battling to attain evolutionary dominance over its neighbors and, in so doing, assure its long-term survival.He traces the evolutionary histories of genes from different organisms, in order to understand the biological forces that shape essential DNA elements.

Malik places a high value on being intellectually fearless — not to be afraid of being wrong. He earned a bachelor’s degree in the chemical engineering from the Indian Institute of Technology, Bombay, but recognized his strong preference for biology while an undergraduate. An introductory course in molecular biology — in particular, the topic of transposons (“jumping genes”) — cemented his new direction and provided the impetus for his immigration from India to the United States in 1993.

He accepted the offer of a prestigious Sproull Fellowship from the University of Rochester, New York, where he quickly proved himself, even winning accolades for teaching an introductory genetics course he had never taken himself. His research focus at this time was on retrotransposons, “selfish” genes, which exploit host organisms to self-perpetuate. His findings essentially rewrote retrotransposon history, demonstrating that these genes were present in evolutionarily ancestral species — not, as believed by most geneticists at the time, spread from one organism to another, like viruses.

In 1999, at the Fred Hutchinson Cancer Research Center (FHCRC) in Seattle, he began postdoc work with investigator Steven Henikoff on centromeres (repetitive sequences of DNA that do not code for proteins), advancing his hypotheses on evolutionary gene conflict.

Today Malik is an associate member of the FHCRC Basic Sciences division and head of his own lab. His future plans include investigating genes identified in the expression of genome-wide association screens for predisposition to cancers.

 

Awards and Accomplishments

  • Presidential Early Career Award in Science and Engineering (2009)
  • Howard Hughes Medical Institute Early Career Scientist Award (2009)
  • National Science Foundation Career Award (2008–2013)

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Jury Members

2010 Vilcek Prize for Creative Promise in Biomedical Science

Heran Darwin

Associate Professor of Microbiology, New York University School of Medicine

Laurie Dempsey

Senior Editor, Nature Immunology

Peter Palese

Professor and Chair, Microbiology, Mount Sinai School of Medicine

Jan Vilcek

Professor of Microbiology, New York University School of Medicine

Leslie Vosshall

Investigator, Howard Hughes Medical Institute, Chemers Family Associate Professor, The Rockefeller University

Nicholas Wade

Science Department, The New York Times

Jedd Wolchok

Director of Immunotherapy, Memorial Sloan Kettering Cancer Center
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biochemistry biology genetics genome Howard Hughes Medical Institute india University of Washington
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