Houra Merrikh receives the Vilcek Prize for Creative Promise in Biomedical Science for demonstrating how conflicts between life-sustaining cellular machines involved in genome duplication and gene expression can accelerate evolution.
Richard Flavell receives the Vilcek Prize in Biomedical Science for his paradigm-shifting efforts to use an approach called reverse genetics to probe the molecular basis of immunity, yielding rich insights into innate and adaptive immunity, autoimmunity, and immune system-microbiome interactions.
Hashim Al-Hashimi receives the Vilcek Prize for Creative Promise in Biomedical Science for using biophysical and computational methods to probe the dynamic properties of life-sustaining biomolecules such as DNA, RNA, and the proteins that interact with them, paving the way toward targeted drug discovery.
Joanna Wysocka receives the Vilcek Prize for Creative Promise in Biomedical Science for uncovering epigenetic mechanisms underlying cell self-renewal and differentiation in work that carries implications for understanding diverse biological processes, including cancer metastasis and embryonic development.
Titia de Lange receives the Vilcek Prize in Biomedical Science for seminal contributions to the biology of telomeres—the aiglet-like structures that protect the ends of chromosomes in living cells—and for discovering telomere-binding proteins that help ensure genome stability and prevent tumor formation.
Joan Massagué receives the Vilcek Prize in Biomedical Science for groundbreaking work in identifying and uncovering the mode of action of cellular receptors for the signaling molecule TGF-beta, which is implicated in processes such as embryonic development, tumor onset, and cancer metastasis.